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Xiaodong JIN, Yuefa FANG, Dan ZHANG, Xueling LUO
《机械工程前沿(英文)》 2020年 第15卷 第1期 页码 66-80 doi: 10.1007/s11465-019-0570-x
关键词: parallel mechanism redundant mechanism large rotational angles machine tools 2R1T spindle head collaborative manipulator
Basic consideration of research strategies for head and neck cancer
null
《医学前沿(英文)》 2012年 第6卷 第4期 页码 339-353 doi: 10.1007/s11684-012-0213-7
Head and neck cancer (HNC) consists of a group of malignancies affecting closely related anatomical regions of the upper aerodigestive tract (UADT), including the oral cavity, salivary glands, upper and lower jaw bones and facial skin; the nasal cavity, paranasal sinuses, pharynx, larynx and thyroid gland (although the latter is often excluded and considered as part of endocrine neoplasms). Of these, 90% of HNCs are histologically squamous cell carcinomas originating from the mucosal lining. These malignancies are strongly associated with certain environmental and life-style risk factors, principally tobacco in both smoked and smokeless forms, excessive alcohol consumption, diets poor in antioxidants and essential micronutrients, UV light, chemicals used in certain workplaces, and viruses, principally certain strains of human papillomavirus (HPV) and Epstein-Barr virus (EBV). These cancers are frequently aggressive in their biological behaviour with local invasion and metastasis to lymph nodes in the neck. Since most patients are already at late stages of disease at the time of diagnosis, the desirable practice of early diagnosis (first sign of the malignant lesion at an initial stage ) and early treatment, a critical priority to save lives and retain quality of life, is difficult to implement. Thus, primary prevention has been set as a key goal. This article aims to reinforce the basic knowledge of aetiology, key risk factors related to the development of head and neck cancer, basic features of clinical appearance of this group of cancers, and strategies for prevention and early detection. We also suggest basic research strategies on the basis of current knowledge, which should ultimately lead to the improvement of clinical management.
关键词: clinical management head and neck cancer prevention and early detection research strategies risk factors
适于低成本嵌入式硬件的2R-1C模型非迭代参数估计 Article
Mitar SIMIĆ, Zdenka BABIĆ, Vladimir RISOJEVIĆ, Goran M. STOJANOVIĆ
《信息与电子工程前沿(英文)》 2020年 第21卷 第3期 页码 476-490 doi: 10.1631/FITEE.1900112
R. WEI, V. RUDOLPH, C. T. WEI, Y. QIN
《化学科学与工程前沿(英文)》 2009年 第3卷 第1期 页码 20-25 doi: 10.1007/s11705-009-0138-0
关键词: multi-scale model gas transport coal coalbed methane CO2 sequestration
Expression pattern and regulation of head-to-head genes
Xinxing CUI,Chunhong YANG,Li KANG,Guiyu ZHU,Qingqing WEI,Yunliang JIANG
《农业科学与工程前沿(英文)》 2014年 第1卷 第2期 页码 130-136 doi: 10.15302/J-FASE-2014013
Screening of potential aquatic probiotics from the major microflora of guppies (
Aparna BALAKRISHNA, T. R. KEERTHI
《化学科学与工程前沿(英文)》 2012年 第6卷 第2期 页码 163-173 doi: 10.1007/s11705-012-1283-4
关键词: aquaculture normal flora immunomodulatory effect probiotic antagonistic principle bacteriocin like inhibitory substances
Modeling of alkali-silica reaction in concrete: a review
PAN, Y.T. FENG, J.T. WANG, Q.C. SUN, C.H. ZHANG, D.R.J. OWEN
《结构与土木工程前沿(英文)》 2012年 第6卷 第1期 页码 1-18 doi: 10.1007/s11709-012-0141-2
关键词: alkali-silica reaction (ASR) modeling concrete mesoscopic macroscopic
Optimization of cellulase production using
Saravanan P, Muthuvelayudham R, Rajesh Kannan R, Viruthagiri T
《化学科学与工程前沿(英文)》 2012年 第6卷 第4期 页码 443-452 doi: 10.1007/s11705-012-1225-1
关键词:
cellulase
pineapple waste
A novel flow electrode capacitive deionization device with spindle-shaped desalting chamber
《环境科学与工程前沿(英文)》 2023年 第18卷 第4期 doi: 10.1007/s11783-024-1800-y
● A spindle-shaped influent chamber was designed and equipped in FCDI system.
关键词: Spindle-shaped chamber Desalination performance Flow electrode capacitive deionization
Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia
《医学前沿(英文)》 2022年 第16卷 第3期 页码 442-458 doi: 10.1007/s11684-021-0877-y
关键词: T-cell acute lymphoblastic leukemia HDAC inhibitor chidamide NOTCH1 MYC ubiquitination
Alberto T. Penteado, Mijin Kim, Hamid R. Godini, Erik Esche, Jens-Uwe Repke
《化学科学与工程前沿(英文)》 2018年 第12卷 第4期 页码 598-618 doi: 10.1007/s11705-018-1752-5
This contribution is a preliminary techno-economic assessment of a biogas-based oxidative coupling of methane (OCM) process. Biogas is frequently utilized as a renewable energy source within small scale combined heat and power plants or as a natural gas substitute. The activation of methane also enables its utilization as a feedstock to produce chemicals. In this sense, the OCM process allows for the direct conversion of methane into ethylene, which is a major building block for the chemical and polymer industries. Biogas resulting from the anaerobic digestion of vinasse, a liquid effluent from bioethanol industry, is treated for contaminant removal and its methane content is converted into ethylene, which is then purified as the main product. The biogas cleaning process is assessed based on literature data, while an experimentally validated simulation model is used to assess the OCM process. A techno-economic evaluation is then performed through a Monte Carlo simulation, wherein uncertain parameters take random values between reasonable bounds. The net present value results positive in 74% of the cases, indicating that the project is profitable under a wide range of scenarios. Some performance improvement opportunities have been identified and highlighted to guide future studies in the topic.
关键词: biogas conversion ethylene production oxidative coupling of methane feasibility study
Treatment technologies for aqueous perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA)
VECITIS, Hyunwoong PARK, Jie CHENG, Brian T. MADER, Michael R. HOFFMANN
《环境科学与工程前沿(英文)》 2009年 第3卷 第2期 页码 129-151 doi: 10.1007/s11783-009-0022-7
关键词: fluorochemical (FC) degradation technologies perfluoroctanesulfonate (PFOS) perfluorooctanoate (PFOA) oxidation reduction photolysis thermolysis review
Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells
LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan
《医学前沿(英文)》 2007年 第1卷 第3期 页码 269-273 doi: 10.1007/s11684-007-0051-1
关键词: 3T3-L1 influence resistance receptor substrate-1 transport
null
《医学前沿(英文)》 2013年 第7卷 第1期 页码 138-142 doi: 10.1007/s11684-013-0247-5
It has been demonstrated that single nucleotide polymorphisms (SNPs) of SIPA1 (signal-induced proliferation associated gene 1) are associated with metastatic efficiency in both human and rodents. The purpose of this study was to determine whether SIPA1 545 C>T polymorphism was associated with overall survival in patients with metastatic breast cancer. In this study, SIPA1 545 C>T polymorphism was detected in 185 metastatic breast cancer patients using polymerase chain reaction-restriction fragment length polymorphism assay (PCR-RFLP). Survival curves for patients with SIPA1 545 C>T polymorphism was compared using the Kaplan-Meier method with log-rank tests. We found that SIPA1 545 C>T polymorphism was significantly associated with survival in 185 patients with metastatic breast cancer. Patients with SIPA1545 T/T genotype had a significantly worse overall survival (OS) than did patients with C/T or C/C genotype (50.0% vs. 62.9%, P = 0.042). Moreover, in multivariate analysis, as compared with the C/C or C/T genotype, the T/T genotype remained an independent unfavorable prognostic marker of OS in this cohort (hazard ratio [HR] = 2.16; 95% CI= 1.12–4.15; P = 0.022). Our findings indicate that metastatic breast cancer patients with SIPA1 545 T/T genotype have a poorer survival compared to patients with C/C or C/T genotype.
Effect on proliferation and apoptosis of T24 cell lines via silencing DNMT1 with RNA interference
ZHANG Shilong, ZENG Fuqing, PENG Shibo, WANG Liang
《医学前沿(英文)》 2008年 第2卷 第4期 页码 374-379 doi: 10.1007/s11684-008-0072-4
标题 作者 时间 类型 操作
Design and analysis of a class of redundant collaborative manipulators with 2-dimension large rotational
Xiaodong JIN, Yuefa FANG, Dan ZHANG, Xueling LUO
期刊论文
适于低成本嵌入式硬件的2R-1C模型非迭代参数估计
Mitar SIMIĆ, Zdenka BABIĆ, Vladimir RISOJEVIĆ, Goran M. STOJANOVIĆ
期刊论文
Expression pattern and regulation of head-to-head genes
Xinxing CUI,Chunhong YANG,Li KANG,Guiyu ZHU,Qingqing WEI,Yunliang JIANG
期刊论文
Screening of potential aquatic probiotics from the major microflora of guppies (
Aparna BALAKRISHNA, T. R. KEERTHI
期刊论文
Modeling of alkali-silica reaction in concrete: a review
PAN, Y.T. FENG, J.T. WANG, Q.C. SUN, C.H. ZHANG, D.R.J. OWEN
期刊论文
Optimization of cellulase production using
Saravanan P, Muthuvelayudham R, Rajesh Kannan R, Viruthagiri T
期刊论文
Techno-economic evaluation of a biogas-based oxidative coupling of methane process for ethylene production
Alberto T. Penteado, Mijin Kim, Hamid R. Godini, Erik Esche, Jens-Uwe Repke
期刊论文
Treatment technologies for aqueous perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA)
VECITIS, Hyunwoong PARK, Jie CHENG, Brian T. MADER, Michael R. HOFFMANN
期刊论文
Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells
LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan
期刊论文
Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer
null
期刊论文